94240-17-2

Usage

Preparation

Preparation by conversion of the base with 35% ethanolic hydrogen chloride.

InChI:InChI=1/C9H11NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,10-11H,6H2,1H3;1H

Upstream product

• 71786-67-9 2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanone hydrochloride 
• 2491-37-4 2-bromo-1-(3-hydroxyphenyl)ethanone 
• 74-89-5 methylamine 

Downstream Products

• 61-76-7 phenylephrine hydrochloride 
• 939-38-8 (+)-Phenylephrine hydrochloride 
• 614-03-9 (S)-phenylephrine 
• 59-42-7 Phenylephrin 
• 679395-42-7 O-acetyl,N-acetylphenylephrone 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS

Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is hydrogen, C1-6alkyl or aryl-substituted C1-6alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoacetophenones in the presence of a ruthenium complex catalyst comprising a chiral phosphine ligand.

PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS

Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R1 is C1-6 alkyl or aryl-substituted C1-6 alkyl and R2 through R6 are independently hydrogen, hydroxy or C1-6 alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoaceto-phenones in the presence of a rhodium complex catalyst comprising a chiral diphosphine ligand, wherein each phosphorus atom is part of a heterocyclic ring system which contains at least one chiral carbon atom directly bound to the phosphorus atom.