942410-53-9Relevant academic research and scientific papers
Radical N-arylation/alkylation of sulfoximines
Zhu, Hui,Teng, Fan,Pan, Changduo,Cheng, Jiang,Yu, Jin-Tao
supporting information, p. 2372 - 2374 (2016/05/19)
A novel copper-catalyzed N-arylation/alkylation of sulfoximines with acyl peroxides as aryl/alkyl source was developed. This approach undergoes a radical pathway, representing an alternative complement to construct N-arylated/alkylated sulfoximines.
Mild copper-TBAF-catalyzed N-arylation of sulfoximines with aryl siloxanes
Kim, Jaeeun,Ok, Jinpyo,Kim, Sanghyuck,Choi, Wonseok,Lee, Phil Ho
supporting information, p. 4602 - 4605 (2015/01/09)
An efficient copper-TBAF-catalyzed C-N bond formation of sulfoximines with arylsiloxanes in dichloromethane at room temperature, affording the desired N-aryl sulfoximines in good to excellent yields under an oxygen atmosphere, is reported. This method complements the existing synthetic approaches due to some advantageous properties of arylsiloxanes such as availability, low toxicity, ease of handling, high stability, and environmental benignity under mild reaction conditions, thus opening a new approach to practical C-N bond formation.
ALKYNYLPYRIMIDINES AS TIE2 KINASE INHIBITORS
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, (2009/01/23)
The invention relates to alkynylpyrimidines according to the general formula (I) in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
SULFOXIMINE-SUBSTITUTED PYRIMIDINES , THEIR PREPARATION AND USE AS DRUGS
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Page/Page column 124-125, (2010/11/27)
The invention relates to sulfoximine-substituted pyrimidines of the general Formula (I) processes for the preparation thereof and their use as kinase inhibitors for treating for example cancer or inflammation.
Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
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Page/Page column 48, (2010/11/28)
The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs.
