942598-36-9Relevant academic research and scientific papers
IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST
-
Paragraph 0916-0917, (2020/08/22)
Disclosed herein is an imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as a TLR7 agonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as TLR7 agonist.
INHIBITORS OF FATTY ACID AMIDE HYDROLASE
-
Paragraph 1109, (2016/01/15)
The present invention provides compounds, and pharmaceutically acceptable compositions thereof, encompassed by any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof.
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core
Shen, Dong-Ming,Brady, Edward J.,Candelore, Mari R.,Dallas-Yang, Qing,Ding, Victor D.-H.,Feeney, William P.,Jiang, Guoquiang,McCann, Margaret E.,Mock, Steve,Qureshi, Sajjad A.,Saperstein, Richard,Shen, Xiaolan,Tong, Xinchun,Tota, Laurie M.,Wright, Michael J.,Yang, Xiaodong,Zheng, Song,Chapman, Kevin T.,Zhang, Bei B.,Tata, James R.,Parmee, Emma R.
scheme or table, p. 76 - 81 (2011/02/27)
A novel class of 1,3,5-pyrazoles has been discovered as potent human glucagon receptor antagonists. Notably, compound 26 is orally bioavailable in several preclinical species and shows selectivity towards cardiac ion channels, other family B receptors suc
MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS
-
Page/Page column 127, (2008/06/13)
The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.
