259099-03-1Relevant articles and documents
Controlling Chemoselectivity of Catalytic Hydroboration with Light
Bergamaschi, Enrico,Chen, Yi-Kai,Hohenadel, Melissa,Lunic, Danijela,McLean, Liam A.,Teskey, Christopher J.
, (2022/01/13)
The ability to selectively react one functional group in the presence of another underpins efficient reaction sequences. Despite many designer catalytic systems being reported for hydroboration reactions, which allow introduction of a functional handle fo
BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS
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Page/Page column 65, (2019/08/26)
The present invention relates to compounds of general formula (I), wherein the groups R1 and R2 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core
Shen, Dong-Ming,Brady, Edward J.,Candelore, Mari R.,Dallas-Yang, Qing,Ding, Victor D.-H.,Feeney, William P.,Jiang, Guoquiang,McCann, Margaret E.,Mock, Steve,Qureshi, Sajjad A.,Saperstein, Richard,Shen, Xiaolan,Tong, Xinchun,Tota, Laurie M.,Wright, Michael J.,Yang, Xiaodong,Zheng, Song,Chapman, Kevin T.,Zhang, Bei B.,Tata, James R.,Parmee, Emma R.
scheme or table, p. 76 - 81 (2011/02/27)
A novel class of 1,3,5-pyrazoles has been discovered as potent human glucagon receptor antagonists. Notably, compound 26 is orally bioavailable in several preclinical species and shows selectivity towards cardiac ion channels, other family B receptors suc
Total synthesis of ovalifoliolatin B, acerogenins A and C
Kishore Kumar,Natarajan, Amarnath
, p. 2103 - 2105 (2008/09/18)
A short and concise route for the synthesis of ovalifoliolatin B, a highly strained macrocyclic diaryl ether heptanoid natural product that also provides quick access to acerogenins A and C natural products has been reported.
Sulfonamido-macrocycles and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof
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Page/Page column 10, (2008/06/13)
The invention relates to sulfonamido-macrocycles according to the general Formula I and the salts thereof, to pharmaceutical compositions comprising the sulfonamido-macrocycles and to a method of preparing the sulfonamido-macrocycles as well as the use th