94278-70-3

Basic information

• Product Name: 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene
• Synonyms: 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene;Benzene, 2-(bromomethyl)-1,3-dichloro-5-methoxy-
• CAS NO: 94278-70-3
• Molecular Formula: C₈H₇BrCl₂O
• Molecular Weight: 269.95058
• Mol File: 94278-70-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene(94278-70-3)
• EPA Substance Registry System: 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene(94278-70-3)

Safety Data

• Hazardous Substances Data: 94278-70-3(Hazardous Substances Data)

Usage

General Description

2-(bromomethyl)-1,3-dichloro-5-methoxybenzene is a chemical compound that belongs to the class of benzene derivatives. It consists of a benzene ring with two chlorine atoms at positions 1 and 3, a methoxy group at position 5, and a bromomethyl group attached to the benzene ring. 2-(bromomethyl)-1,3-dichloro-5-methoxybenzene is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in various organic reactions and can serve as a building block for the creation of more complex molecules. It is important to handle this compound with caution, as it is toxic and may cause irritation to the skin, eyes, and respiratory system if proper safety measures are not taken.

Upstream product

• 94278-65-6 methyl 2,6-dichloro-4-methoxybenzoate 
• 60964-09-2 2,6-dichloro-4-hydroxybenzaldehyde 
• 82772-93-8 2,6-dichloro-4-methoxy-benzaldehyde 
• 461031-79-8 4-(benzyloxy)-2,6-dichlorobenzaldehyde 
• 126663-61-4 1-<(tert-butyldimethylsilyl)oxy>-3,5-dichlorobenzene 
• 591-35-5 3,5-dichlorophenol 

Downstream Products

• 911724-17-9 3-(2,6-dichloro-4-methoxy-benzyl)-1-(1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one 
• 956319-22-5 2,6-dichloro-4-methoxy-benzylamine hydrochloride 
• 955406-96-9 3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one 
• 955407-60-0 3,5-Dichloro-N-isobutyl-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-benzamide 
• 955406-24-3 C₂₇H₂₄Cl₂F₃N₃O₅S 
• 956125-90-9 (R)-3-(2,6-dichloro-4-methoxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one hydrochloride 
• 956125-95-4 (R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid 
• 956125-94-3 (R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid methyl ester 
• 956125-93-2 (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-phenyl ester 
• 956125-92-1 (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one 
• 956125-89-6 (R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde 
• 622861-26-1 4-(2,6-dichloro-4-methoxyphenyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione 
• 622861-25-0 4-(2,6-dichloro-4-methoxy-phenyl)-9-methoxy-4,5,6,10c-tetrahydro-3aH-pyrrolo[3,4-c]carbazole-1,3-dione 
• 622861-24-9 2-[(E)-2-(2,6-dichloro-4-methoxyphenyl)ethenyl]-5-methoxy-1H-indole 

Relevant articles and documents

NOVEL COMPOUNDS

Described herein are compounds that are inhibitors of p21-activated kinases (PAKS). In particular, the compounds described herein are demonstrated to be selective PAK4 inhibitors. The compounds described herein are also demonstrated to reduce the expression of key immune checkpoint molecules, such as PD-1 and CHEK2. Also described herein are pharmaceutical compositions containing such compounds, methods for using such compounds in the treatment of cancers, more specifically, the treatment of pancreatic and lung cancers, and to related uses.

INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

The present invention discloses novel compounds of Formula I: (I) having 11 -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11 -HSD type 1 activity.

SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

The present invention discloses novel compounds of Formula I: ( I ) possessing 11β -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 β -HSD type 1 activity.