943010-71-7

Upstream product

• 100-52-7 benzaldehyde 
• 1961-97-3 3-phenyl-1H-indene 
• 124-38-9 carbon dioxide 
• 14251-57-1 1,1-diphenyl-1,2-propadiene 
• 210752-49-1 ethyl (2Z)-2-(1-hydroxy-1-phenylmethyl)-3-phenylacrylate 
• 118215-71-7 3-phenyl-1H-indene-2-carboxylic acid ethyl ester 

Downstream Products

• 101110-07-0 1-phenyl-indan-2-carboxylic acid 
• 66528-17-4 1-oxo-3-phenyl-1H-indene-2-carboxylic acid 

Relevant academic research and scientific papers

AlBr3-mediated tandem cyclizationcarboxylation of allenylbenzenes with CO2 in the presence of pyridines

Indene-2-carboxylic acids are prepared from allenylbenzenes and CO2 by an AlBr3-mediated tandem reaction consisting of intramolecular FriedelCrafts alkylation of allenylbenzenes and subsequent carbonation of the resulting indenylaluminum species. The reaction requires 2,6- di-tert-butylpyridine or 2,6-diiodopyridine to neutralize an acidic by-product without deactivating the Lewis acid.

Transfer of Chirality in the Rhodium-Catalyzed Chemoselective and Regioselective Allylic Alkylation of Hydroxyarenes with Vinyl Aziridines

By taking advantage of chirality-transfer strategy, a chemo- and regioselective allylic alkylation of naphthols and phenols with vinylaziridines provides an atom-economic and efficient method for the synthesis of enantioenriched 2-vinyl-2-arylethylamine derivatives. Use of readily available starting materials, a broad substrate scope, high selectivity, mild reaction conditions, as well as versatile functionalizations of the aromatic ethylamine products make this approach very practical and attractive.

EtAlCl2/2,6-Disubstituted Pyridine-Mediated Carboxylation of Alkenes with Carbon Dioxide

α-Arylalkenes and trialkyl-substituted alkenes undergo carboxylation with CO2 in the presence of EtAlCl2 and 2,6-dibromopyridine to afford the corresponding α,β- and/or β,γ-unsaturated carboxylic acids. This reaction is suggested to proceed via the electrophilic substitution of EtAlCl2 with the aid of the base, followed by the carbonation of the resulting ate complex. This reaction can be applied to terminal dialkylalkenes by using a mixture of 2,6-di-tert-butylpyridine and 2,6-dibromopyridine.