943437-44-3

Upstream product

• 50-00-0 formaldehyd 
• 94226-55-8 (dibenzylamino)acetic acid methyl ester 
• 103-49-1 dibenzylamine 
• 5619-04-5 methyl 2-amino-3-hydroxypropanoate hydrochloride 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 

Downstream Products

• 943437-45-4 methyl 2-dibenzylamino-3-difluoromethoxy-propionate 
• 344413-78-1 (2R)-3-(dibenzylamino)-2-fluoropropan-1-ol 
• 1609546-34-0 (R)-N,N-dibenzyl-2-fluoro-3-methoxypropan-1-amine 
• 88099-68-7 methyl (2R)-3-N,N-dibenzylamino-2-fluoropropanoate 

Relevant academic research and scientific papers

Radical 1,4-Aryl Migration Enabled Remote Cross-Electrophile Coupling of α-Amino-β-Bromo Acid Esters with Aryl Bromides

We report an unprecedented, efficient nickel-catalysed radical relay for the remote cross-electrophile coupling of β-bromo-α-benzylamino acid esters with aryl bromides via 1,4-aryl migration/arylation cascades. β-Bromo-α-benzylamino acid esters are consid

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Deoxyradiofluorination Reaction from β-Hydroxy-α-aminoesters: an Entry to [18F]Fluoroaminoesters under Mild Conditions

We report the conversion of β-hydroxy-α-aminoesters derived from serine, α-methylserine or β-phenylserine to the corresponding [18F]fluorinated α or β-aminoesters by deoxyradiofluorination using [18F]fluoride. The method involved the

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

COMPOUNDS AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS

Provided are certain Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

HETEROARYL SUBSTITUTED NICOTINAMIDE COMPOUNDS

Disclosed are compounds of Formula (I) or salts thereof, wherein: HET is a heteroaryl selected from pyrazolyl, indolyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-d]pyrimidinyl, pyrazolo[3,4-b]pyridinyl, pyrazolo[3,4-d]pyrimidinyl, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridinyl, imidazo[4,5-b]pyridinyl, and purinyl, wherein said heteroaryl is substituted with Ra and Rb; and R1 and R2 are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.

FLUORINATED COMPOUNDS

Compounds of Formula I are useful in the treatment of epilepsy, neuropathic pain, acute and chronic inflammatory pain, migraine, tardive dyskinesia and other related CNS disorders. wherein: A and R1 to R8 are defined in the specification.