94360-67-5

Upstream product

• 148859-87-4 piperidinium salt of 4,6-diphenyl-3-cyano-1,4-dihydropyridine-2-thiol 
• 58327-74-5 4,6-diphenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 79-07-2 Chloroacetamide 
• 112475-75-9 2-(3-Cyano-4,6-diphenyl-1,4-dihydro-pyridin-2-ylsulfanyl)-acetamide 
• 683-57-8 bromo-acetic acid amide 

Downstream Products

• 94639-67-5 3-amino-4,6-diphenylthieno[2,3-b]pyridine-2-carboxamide 
• 94639-65-3 2-methyl-7,9-diphenyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one 

Relevant academic research and scientific papers

CYCLIZATION OF NITRILES. XI. SYNTHESIS AND REACTIONS OF 3-AMINO-2-CARBOXYTHIENOPYRIDINES

Derivatives of 3-cyano-2-pyridylthioacetic acid were synthesized by the reaction of substituted 3-cyano-2(1H)-pyridinethiones with monobromoacetic acid.They were converted by the Thorpe-Ziegler reaction into the corresponding 3-amino-2-carboxythieno2,3-b

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.