94360-69-7

Upstream product

• 683-57-8 bromo-acetic acid amide 
• 78564-17-7 3-cyano-4-(4-methoxyphenyl)-6-phenylpyridine-2(1H)-thione 
• 79-07-2 Chloroacetamide 
• 109012-86-4 3-(4-methoxyphenyl)-2-cyano-5-phenyl-5-oxo-pentano-nitrile 
• 94360-16-4 2-Bromo-2-[1-(4-methoxy-phenyl)-3-oxo-3-phenyl-propyl]-malononitrile 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 68029-57-2 2-cyano-3-(4-methoxyphenyl)thioacrylamide 

Relevant academic research and scientific papers

Unexpected formation of 4-aryl-3-cyano-6-phenylpyridine-2(1H)-thiones from the reaction of arylmethylenecyanothioacetamides with benzoyl-1,1,1- trifluoroacetone

4-Aryl-3-cyano-6-phenylpyridine-2(1H)-thiones, used in the synthesis of substituted 2-alkylthiopyridines, thieno[2,3-b]pyridines, and 1,4-di(pyridin-2-ylthio)butane, have been synthesized by the condensation of arylmethylenecyanothioacetamides with benzoyl-1,1,1-trifluoroacetone. The reaction path includes the formation of the Michael adduct which undergoes loss of the acyl group. The structure of 3-cyano-2-methylthio-4-(1-naphthyl)-6- phenylpyridine has been studied by X-ray crystallography. 2005 Springer Science+Business Media, Inc.

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.