94385-68-9Relevant academic research and scientific papers
3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation
Shi, Wei-Kang,Deng, Rui-Cheng,Wang, Peng-Fei,Yue, Qin-Qin,Liu, Qi,Ding, Kun-Ling,Yang, Mei-Hui,Zhang, Hong-Yu,Gong, Si-Hua,Deng, Min,Liu, Wen-Run,Feng, Qiu-Ju,Xiao, Zhu-Ping,Zhu, Hai-Liang
, p. 4519 - 4527 (2016/09/13)
Helicobacter pylori urease is involved in several physiologic responses such as stomach and duodenal ulcers, adenocarcinomas and stomach lymphomas. Thus, inhibition of urease is taken for a good chance to treat H. pylori-caused infections, we have therefore focused our efforts on seeking novel urease inhibitors. Here, a series of arylpropionylhydroxamic acids were synthesized and evaluated for urease inhibition. Out of these compounds, 3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropionylhydroxamic acid (d24) was the most active inhibitor with IC50of 0.15?±?0.05?μM, showing a mixed inhibition with both competitive and uncompetitive aspects. Non-linear fitting of kinetic data gives kinetics parameters of 0.13 and 0.12?μg·mL?1for Kiand Ki′, respectively. The plasma protein binding assays suggested that d24 exhibited moderate binding to human and rabbit plasma proteins.
Synthesis of β-hydroxy esters using highly active manganese
Suh, YoungSung,Rieke, Reuben D.
, p. 1807 - 1809 (2007/10/03)
A modified Reformatsky reaction is reported using highly reactive manganese (Mn*). The active manganese was found to readily react with α-haloester in the presence of aldehydes and ketones to yield the corresponding β-hydroxy esters. The reaction is carried out at room temperature in the absence of Lewis acid or trapping agents.
Arylpropane-1,3-diols in lignins from normal and CAD-deficient pines
Ralph, John,Kim, Hoon,Peng, Junpeng,Lu, Fachuang
, p. 323 - 326 (2008/02/12)
(equation presented) Significant quantities of arylpropane-1,3-diols have been identified in lignins isolated from a CAD-deficient pine mutant; smaller amounts are also present in lignins from normal pine. They arise from dihydroconiferyl alcohol via the action of peroxidases which are responsible for the radical generation steps of lignification. The structures in the complex lignin polymers are proven using 2D and 3D NMR of isolated lignin fractions.
Synthesis of oligomeric mimics of lignin
Ciofi-Baffoni, Simone,Banci, Lucia,Brandi, Alberto
, p. 3207 - 3217 (2007/10/03)
The preparation of β-O-4 oligomeric compounds that mimic the lignin structure is pertinent to the study of the mechanism of action of lignin-degrading enzymes. A strategy for the synthesis of racemic oligomers β-O-4 phenolic models of lignin is reported h
