943960-89-2Relevant articles and documents
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones
Gutteridge, Clare E.,Hoffman, Marshall M.,Bhattacharjee, Apurba K.,Milhous, Wilbur K.,Gerena, Lucia
scheme or table, p. 786 - 789 (2011/03/17)
A series of 1,7-diaminoisoquinolinamines, that are expected to mediate antimalarial activity by the same mechanism employed by the chalcones, were produced. Six 7-benzylamino-1-isoquinolinamines were found to be submicromolar inhibitors in vitro of drug-r
Synthesis and antimalarial activity of 7-benzylamino-1-isoquinolinamines
Gutteridge, Clare E.,Hoffman, Marshall M.,Bhattacharjee, Apurba K.,Gerena, Lucia
, p. 633 - 637 (2008/09/17)
(Chemical Equation Presented) Computer modelling suggests that 7-benzylamino-1-isoquinolinamines should mediate antimalarial effects by a mechanism distinct from that employed by existing antimalarial drugs. A series of these compounds was prepared in sev