943976-22-5

Basic information

• Product Name: 4-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexane carboxamide
• Synonyms: Mefway; N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-fluoromethylcyclohexane)carboxamide
• CAS NO: 943976-22-5
• Molecular Formula: C₂₆H₃₅FN₄O₂
• Molecular Weight: 454.58
• Mol File: 943976-22-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexane carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexane carboxamide(943976-22-5)
• EPA Substance Registry System: 4-(fluoromethyl)-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexane carboxamide(943976-22-5)

Safety Data

• Hazardous Substances Data: 943976-22-5(Hazardous Substances Data)

Upstream product

• 943962-57-0 methyl 4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylate 
• 946530-08-1 C₂₆H₃₆N₄O₃ 
• 146714-63-8 4-(2-methoxyphenyl)-1-(2-pyridinylaminocarbonyl)methylpiperazine 
• 504-29-0 2-aminopyridine 
• 5221-37-4 2-chloro-N-pyridin-2-ylacetamide 
• 946530-10-5 (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate 
• 155204-28-7 1-(2-methoxyphenyl)-4-(2-(2-pyridylamino)ethyl)piperazine 
• 13170-66-6 trans-1,4-cyclohexanedicarboxylic acid dichloride 
• 619-82-9 trans-hexahydroterephthalic acid 
• 1421268-46-3 (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid 
• 946530-07-0 (1r,4r)-4-(hydroxymethyl)-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide 
• 407628-30-2 trans-1,4-cyclohexane dicarboxylic acid 
• 943962-58-1 4-(hydroxymethyl)-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide 

Relevant articles and documents

Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors

18F-Mefway (N-{2-[4-(2′methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4′18F-fluoro-methylcyclohexane)carboxamide) was developed and evaluated for use as a PET ligand for imaging 5-HT1A receptors. Ongoing studies of sup

NOVEL SYNTHESIS METHOD

The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT1A. The method of the present invention provides advantages over the known methods of synthesis. The compounds

5HT1A ANTAGONIST USEFUL FOR IN VIVO IMAGING

The present invention provides a novel compound of formula (I) useful for in vivo imaging of 5-HT1 A receptors in a subject. Also provided by the present invention is a precursor compound useful in the preparation of the compound of the inventi

COMPOSITIONS AND METHODS RELATED TO SEROTONIN 5-HT1A RECEPTORS

Contemplated substituted arylpiperazinyl compounds, and most preferably 18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high b