944086-09-3

Basic information

• Product Name: Ethanone, 1-(7-broMo-1H-indol-3-yl)-
• Synonyms: Ethanone, 1-(7-broMo-1H-indol-3-yl)-;1-(7-BroMo-1H-indol-3-yl)ethanone;1-(7-bromo-1H-indol-3-yl)ethan-1-one
• CAS NO: 944086-09-3
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• Mol File: 944086-09-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 190-191 °C
• Boiling Point: 389.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.591±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.71±0.30(Predicted)
• CAS DataBase Reference: Ethanone, 1-(7-broMo-1H-indol-3-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(7-broMo-1H-indol-3-yl)-(944086-09-3)
• EPA Substance Registry System: Ethanone, 1-(7-broMo-1H-indol-3-yl)-(944086-09-3)

Safety Data

• Hazardous Substances Data: 944086-09-3(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(7-bromo-1H-indol-3-yl)- is a chemical compound with the molecular formula C11H8BrNO. It is a synthetic derivative of the indole compound, which is commonly found in various natural products and pharmaceuticals. This particular chemical is often used in research and chemical synthesis as a building block for the creation of other compounds. It has potential applications in the development of new pharmaceuticals and materials due to its unique structure and properties. However, like all chemical compounds, it should be handled with care and used in accordance with proper safety protocols.

Upstream product

• 51417-51-7 7-bromo-1H-indole 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 1311395-15-9 N-[4-(methylphenyl)sulfonyl]-3-acetyl-7-bromo-1H-indole 
• 1311395-36-4 4-(7-bromo-1H-indol-3-yl)-5-(3-methoxyphenyl)pyrimidin-2-amine 
• 1311395-32-0 4-(7-bromo-1H-indol-3-yl)-5-(4-trifluoromethylphenyl)pyrimidin-2-amine 
• 1311395-28-4 4-[2-amino-4-(7-bromo-1H-indol-3-yl)pyrimidin-5-yl]benzamide 
• 1311395-24-0 4-(7-bromo-1H-indol-3-yl)-5-(4-acetylphenyl)pyrimidin-2-amine 

Relevant articles and documents

Rh(III)-Catalyzed [5 + 1] Annulation of Indole-enaminones with Diazo Compounds to Form Highly Functionalized Carbazoles

A novel Rh(III)-catalyzed C-H activation/annulation cascade of indole-enaminones with diazo compounds was reported to construct diversely functionalized carbazole frameworks. The most notable characteristic is that this transformation could smoothly furnish a novel [5 + 1] cyclization product with good to excellent yields (up to 95%), accompanied by the thorough removal of acetyl and N,N-dimethyl groups of two substrates from the target products, rather than the normally expected [4 + 2] cyclization products.

Rhodium(III)-Catalyzed Regioselective Direct C4-Alkylation and C2-Annulation of Indoles: Straightforward Access to Indolopyridone

A straightforward RhIII-catalyzed strategy was developed for the site-selective C4-alkylation and C2-annulation of indole by using electronically variable diazo esters. The transformation was accomplished with the assist of an oxime directing group at the C3 position of the indole core with wide scope and functional-group tolerance. The method directly provided an indolopyridone core. The selectivity was triggered by the reactivity of the diazo coupling partner.

Palladium-catalyzed regioselective C-H fluoroalkylation of indoles at the C4-position

An exclusive catalytic C4-selective fluoroalkylation of indoles with highly active (1H, 1H-perfluoroalkyl)mesityliodonium triflate has been described. The key to its high regioselectivity is the appropriate choice of an easily accessible, cheap and removable directing group at the C3 position in the presence of a Pd(OAc)2 catalyst. Besides indole fluoroalkylation, the application of this strategy in other heteroarenes such as benzo[b]thiophene is also described.