94427-22-2Relevant academic research and scientific papers
Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor
Fischer, Thomas,Riedl, Rainer
, (2017/09/25)
Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan. MMP-7 is a validated target for the development of small molecule drugs against cancer. MMP-13 is within the enzyme class the most efficient contributor to type II collagen degeneration and is a validated target in arthritis and cancer. We have developed the dual MMP-7/-13 inhibitor ZHAWOC6941 with IC50-values of 2.2 μM (MMP-7) and 1.2 μM (MMP-13) that is selective over a broad range of MMP isoforms. It spares MMP-1, -2, -3, -8, -9, -12 and -14, making it a valuable modulator for targeted polypharmacology approaches.
Highly efficient preparation of selectively isotope cluster-labeled long chain fatty acids via two consecutive Csp3-Csp3 cross-coupling reactions
Lethu, Sebastien,Matsuoka, Shigeru,Murata, Michio
supporting information, p. 844 - 847 (2014/03/21)
An efficient synthesis involving two copper-catalyzed alkyl-alkyl coupling reactions has been designed to easily access doubly isotope-labeled fatty acids. Such NMR- and IR-active compounds were obtained in excellent overall yields and will be further used for determining the conformation of an alkyl chain of lipidic biomolecules upon interaction with proteins.
Novel Antitumor Agents CI-920, PD 113270 and PD 113271. 3. Structure Determination.
Hokanson, Gerard C.,French, James C.
, p. 462 - 466 (2007/10/02)
The chemical structures for the novel phosphate-containing antitumor agents CI-920 (1), PD 113270 (2), and PD 113271 (3) were determined by a combination of spectra and chemical means.Extensive analysis of NMR spectral data allowed tentative structures to be assigned for these compounds and their derivatives.These structures were confirmed by reducing CI-920 to 8-methyl-1-octadecanol and by cleaving dephosphorylated CI-920 (7) with sodium periodate to identified products.
