944275-72-3

Upstream product

• 1816-92-8 Methyl azidoacetate 
• 1122-91-4 4-bromo-benzaldehyde 
• 637-81-0 ethyl-2-azidoacetate 
• 124-41-4 sodium methylate 

Downstream Products

• 372089-59-3 6-bromoindole 2-carboxylic acid methyl ester 
• 1362861-42-4 2-hydroxy-9-(4-methoxyphenyl)chromeno[3,4-b]indol-6(7H)-one 
• 1362861-02-6 methyl 6-(4-methoxyphenyl)-1H-indole-2-carboxylate 
• 1362861-04-8 methyl 3-iodo-6-(4-methoxyphenyl)-1H-indole-2-carboxylate 
• 1362861-24-2 methyl 3-(2,5-bis(methoxymethoxy)phenyl)-6-(4-methoxyphenyl)-1H-indole-2-carboxylate 
• 817618-10-3 methyl (S)-3-(4-bromophenyl)-2-hydroxypropionate 
• 2166118-09-6 C₁₀H₁₁BrO₃ 
• 2166118-09-6 3-(4-bromophenyl)-2-hydroxypropionic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: A novel DYRK1A inhibitor class

A library of substituted chromeno[3,4-b]indoles was developed as Lamellarin isosters. Synthesis was achieved from indoles after a four-step pathway sequence involving C-3 iodination, a Suzuki cross-coupling reaction, and a one pot deprotection/lactonisation step. Twenty final compounds were tested in order to determine their activity against topoisomerase I and kinases, the two major biological activities of Lamellarins. One newly synthesized derivative exhibited a strong topoisomerase activity comparable to reference compounds such as campthotecin and Lamellarin with only a weak kinase inhibition. Two other lead compounds were identified as new nanomolar DYRK1A inhibitors and several other drugs affected the kinases in the sub-micromolar range. These results will enable us to use the chromeno[3,4-b]indole as a pharmacophore to develop potent treatments for neurological or oncological disorders in which DYRK1A is fully involved.

[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source

The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones have been accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation using aryl azides as nitrogen source.