944393-40-2Relevant academic research and scientific papers
NOVEL PSYMBERIN DERIVATIVES, COMPOSITIONS, AND THEIR USE AS ANTINEOPLASTIC AGENTS
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Page/Page column 123, (2010/01/30)
The present invention provides compounds according to Formula (I): or pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers thereof, wherein: ring A, n, q, R1, R2, R3, R4, R5, R6, each R7, each R7A, and R8 are each selected independently of each other and as defined herein. The invention also provides pharmaceutical compositions comprising such compounds (optionally in combination with one or more additional active ingredients), and methods for their use in treating or preventing a wide range of cancers.
New applications of PhI(OAc)2 in synthesis: Total synthesis and SAR development of potent antitumor natural product psymberin/irciniastatin A
Shao, Ning,Huang, Xianhai,Palani, Anandan,Aslanian, Robert,Buevich, Alexei,Piwinski, John,Huryk, Robert,Seidel-Dugan, Cynthia
experimental part, p. 2855 - 2872 (2010/03/05)
A novel PhI(OAc)2-mediated oxidative cyclization reaction is discovered for the synthesis of a-oxy N-acyl aminals and hemiaminals in good yields from readily synthesized N-acyl enamines. This methodology represents a cascade process to construct the core structure of the pederin family of natural products. The total synthesis of psymberin, a member of the pederin family, is accomplished using this ring-closure reaction as the key step. This new method is further showcased in the preparation of advanced psymberin analogues. The biological data of these analogues are presented. Georg Thieme Verlag Stuttgart.
The total synthesis of psymberin
Huang, Xianhai,Shao, Ning,Palani, Anandan,Aslanian, Robert,Buevich, Alexei
, p. 2597 - 2600 (2008/02/08)
The total synthesis of a new member of the pederin family of natural products, psymberln 1, was accomplished. Using a recently reported novel and efficient Phl(OAc)2 mediated oxldatlve entry to 2-(N-acylaminal)- substituted tetrahydropyrans as
