944405-43-0Relevant articles and documents
Direct palladium-catalyzed alkynylation of N-fused heterocycles
Seregin, Ilya V.,Ryabova, Victoria,Gevorgyan, Vladimir
, p. 7742 - 7743 (2007)
The first example of direct C-H alkynylation of electron-rich heteroaromatics has been demonstrated. This mild, simple, and general method allows for the efficient synthesis of diverse alkynyl heterocycles. Kinetic isotope effect studies support an electrophilic substitution pathway for this transformation. Copyright
Pd-Catalyzed C-3 functionalization of indolizines via C-H bond cleavage
Zhao, Baoli
supporting information; experimental part, p. 7108 - 7119 (2012/09/25)
New transition metal-catalyzed methods for the arylation of indolizines by the direct cleavage of C-H bonds have been developed. A wide range of aryltrifluoroborate salts react with indolizines in the presence of Pd(OAc) 2 catalyst and AgOAc oxidant to give the arylated indolizines in high yields. Both electron-donating and electron-withdrawing groups perform smoothly while bromide and chlorine substituents are tolerated. In addition, the indolizines display similar reactivities in the Pd-catalyzed reaction with 3-phenylpropiolic acid to afford the corresponding C-3 alkynylated indolizines. These methods allow the direct functionalization of indolizines in one step.
