94475-65-7

Upstream product

• 16867-04-2 dihydroxypyridine 
• 100-39-0 benzyl bromide 
• 94475-64-6 3-benzyloxy-2-hydroxypyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 19365-01-6 1-methyl-3-hydroxy-2(1H)-pyridinone 
• 33341-99-0 3-hydroxy-1-methyl-2-piperidinone 
• 37463-96-0 1-Methyl-3-(phenyl-hydrazono)-piperidin-2-one 

Relevant academic research and scientific papers

SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

SYNTHESIS WITH HYDROXYLACTAMES III A FACILE ENTRY TO THE 1-OXO-β-CARBOLINE SKELETON. SYNTHESIS OF STRYCHNOCARPINE

Strychnocarpine 1c is synthesized via hydrogenation of 1-methyl-3-hydroxypyridone(2) with Ru/C.Fischer indole cyclization of phenylhydrazone 11 yields 1c.