945-97-1

Usage

InChI:InChI=1/C11H12Cl2O/c12-8-2-1-3-11(14)9-4-6-10(13)7-5-9/h4-7H,1-3,8H2

Upstream product

• 6280-87-1 δ-chlorovaleronitrile 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 108-90-7 chlorobenzene 
• 78195-98-9 1-(4-chlorophenyl)cyclopentan-1-ol 
• 1119-46-6 5-chloro-valeric acid 

Downstream Products

• 120590-00-3 hexahydro-1,3-dimethyl-8a-(4-chlorophenyl)<1,2,4>triazolo<1,5-a>pyridine-2(3H)-thione 
• 120589-94-8 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-N-methyl-1H-1,2-diazepine-1-carbothioamide 
• 1037716-76-9 1-(4-chlorophenyl)-5-chloropentanol 

Relevant academic research and scientific papers

Regioselective Synthesis of Carbonyl-Containing Alkyl Chlorides via Silver-Catalyzed Ring-Opening Chlorination of Cycloalkanols

A novel and regioselective approach to carbonyl-containing alkyl chlorides via silver-catalyzed ring-opening chlorination of cycloalkanols is reported. Concurrent C(sp3)-C(sp3) bond cleavage and C(sp3)-Cl bond formation efficiently occur with good yields under mild conditions, and the chlorinated products are readily transformed into other useful synthetic intermediates and drugs. The reaction features complete regioselectivity, high efficiency, and excellent practicality. (Chemical Equation Presented).

The search of novel inhibitors of HIV-1 Integrase among 5-(4-Halogenophenyl)-5-oxopentyl derivatives of nucleic bases

New nucleic base derivatives were obtained by alkylation of uracil, thymine, cytosine, adenine, 6-chloropurine, and 2-Amino-6-chloropurine with 5-chloro-1-(4-halogenophenyl)-1-pentanones, and their physical and chemical properties were studied. The influe

1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies

New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 μg/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC ≤ 5 μg/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.

Synthesis and some properties of 6-(ω-aroylbutylthio)purines

A series of 6-(ω-aroylthio)purines, which have not been described in the literature, has been obtained by the reaction of 6-purinethione with ω-chlorovalerophenone and its substituted derivatives. Some properties of the compounds synthesized have been studied, viz. reaction at the carbonyl group, methylation, and hydrolysis. 1999 KluwerAcademic/Plenum Publishers.