94527-40-9Relevant academic research and scientific papers
Copper-catalyzed allylations of zirconocene intermediates generated from o-alkenyl or o-alkynylbenzyl ether derivatives and zirconocene-butene complex
Ikeuchi, Yutaka,Taguchi, Takeo,Hanzawa, Yuji
, p. 756 - 759 (2007/10/03)
(Chemical Equation Presented) o-Alkenyl or alkynyl benzylzirconocene intermediate, which was readily generated by the reaction of 2-alkoxymethyl-styrene or 2-alkoxymethyl-1-(trimethylsilylethynyl)-benzene derivative with zirconocene-butene complex (Negishi reagent, "Cp 2Zr"), reacted with allyl or propargyl halides in the presence of a catalytic amount of CuCl to give allylation or allenylation products. Conversion to Dane's diene, which is a key intermediate for estrone synthesis, was efficiently carried out by enyne olefin metathesis of the allylation products.
Synthetic Study of Selective Benzylic Oxidation
Wang, Wuyi,Li, Tiechao,Attardo, Giorgio
, p. 6598 - 6602 (2007/10/03)
Oxidation of bisbenzyl ethers was studied using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ). Compared to other benzylic oxidations such as Kornblum type reaction of benzyl bromides or MnO2 oxidation of benzyl alcohols, DDQ oxidation offered advantages of being mild and highly selective to provide monoaldehyde products. We have explored factors which influence the course of the reaction and exemplified the synthetic value of the approach by preparing a number of aromatic intermediates (7-8, 15-25).
AN IMPROVED SYNTHESIS OF 7-METHOXYISOCHROMAN-3-ONE: A SYNTHON FOR GENERATION OF o-QUINODIMETHANES
Kanapure, S. P.,Das, K. G.,Bhawal, B. M.
, p. 1205 - 1212 (2007/10/02)
7-Methoxyisochroman-3-one (8) has been synthesized from 2-bromo-5-methoxybenzyl methyl ether (3) in overall high yield.
