945462-84-0Relevant articles and documents
A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome
van Swieten, Paul F.,Samuel, Emlyn,Hernandez, Rosa Orient,van den Nieuwendijk, Adrianus M.C.H.,Leeuwenburgh, Michiel A.,van der Marel, Gijsbert A.,Kessler, Benedikt M.,Overkleeft, Herman S.,Kisselev, Alexei F.
, p. 3402 - 3405 (2007)
The ubiquitin-proteasome pathway degrades the majority of proteins in mammalian cells and plays an essential role in the generation of antigenic peptides presented by major histocompatibility class I molecules. Proteasome inhibitors are of great interest
Thrombin-Inhibiting Anticoagulant Liposomes: Development and Characterization
Endreas, Wegderes,Brüssler, Jana,Vornicescu, Doru,Keusgen, Michael,Bakowsky, Udo,Steinmetzer, Torsten
supporting information, p. 340 - 349 (2016/02/16)
Many peptides and peptidomimetic drugs suffer from rapid clearance in vivo; this can be reduced by increasing their size through oligomerization or covalent conjugation with polymers. As proof of principle, an alternative strategy for drug oligomerization
Water soluble multi-biotin-containing compounds
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Page/Page column 24-25, (2010/11/24)
Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water-soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds also are disclosed.
