945473-55-2Relevant academic research and scientific papers
Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK
Kitagawa, Hideo,Ozawa, Tomohiro,Takahata, Sho,Iida, Maiko,Saito, Jun,Yamada, Mototsugu
, p. 4710 - 4720 (2007)
FabI and FabK are bacterial enoyl-acyl carrier protein (ACP) reductases that catalyze the final and rate-limiting step of bacterial fatty acid biosynthesis (FAS) and are potential targets of novel antibacterial agents. We have reported 4-pyridone derivati
Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity
Jones, Jesse A.,Prior, Allan M.,Marreddy, Ravi K. R.,Wahrmund, Rebecca D.,Hurdle, Julian G.,Sun, Dianqing,Hevener, Kirk E.
, p. 1528 - 1535 (2019/07/09)
Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high, and multiple recurrences are not uncommon. Causes inc
