945546-89-4Relevant articles and documents
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
Stammers, Timothy A.,Coulombe, René,Rancourt, Jean,Thavonekham, Bounkham,Fazal, Gulrez,Goulet, Sylvie,Jakalian, Araz,Wernic, Dominic,Tsantrizos, Youla,Poupart, Marc-André,B?s, Michael,McKercher, Ginette,Thauvette, Louise,Kukolj, George,Beaulieu, Pierre L.
, p. 2585 - 2589 (2013/06/27)
A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a-c and 12a-c from a weak-binding fragment-like structure 1 as a starting point.
SUBSTITUTED AMINO-QUINAZOLINONES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE
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Page/Page column 16, (2010/10/19)
The present invention relates to substituted amino-quinazolinones of general formula (I) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
VIRAL POLYMERASE INHIBITORS
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Page/Page column 51, (2009/04/25)
Compounds of formula I: wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
VIRAL POLYMERASE INHIBITORS
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Page/Page column 65, (2010/11/28)
Compounds of formula (I): wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
