945655-37-8

Basic information

• Product Name: ETHYL 6-AMINO-2-METHYL-1H-INDOLE-3-CARBOXYLATE
• Synonyms: ETHYL 6-AMINO-2-METHYL-1H-INDOLE-3-CARBOXYLATE;1H-Indole-3-carboxylic acid, 6-amino-2-methyl-, ethyl ester
• CAS NO: 945655-37-8
• Molecular Formula: C12H14N2O2
• Molecular Weight: 218.25
• Mol File: 945655-37-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 417.5°C at 760 mmHg
• Flash Point: 206.3°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 3.53E-07mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: 2-8°C
• PKA: 17.22±0.30(Predicted)
• CAS DataBase Reference: ETHYL 6-AMINO-2-METHYL-1H-INDOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 6-AMINO-2-METHYL-1H-INDOLE-3-CARBOXYLATE(945655-37-8)
• EPA Substance Registry System: ETHYL 6-AMINO-2-METHYL-1H-INDOLE-3-CARBOXYLATE(945655-37-8)

Safety Data

• Hazardous Substances Data: 945655-37-8(Hazardous Substances Data)

Usage

General Description

Ethyl 6-amino-2-methyl-1H-indole-3-carboxylate is a chemical compound with the molecular formula C13H15N3O2. It is an ester of a carboxylic acid group and is composed of an indole ring that contains a methyl and an amino group. Ethyl 6-amino-2-methyl-1H-indole-3-carboxylate is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various compounds with potential biological activity. It has been studied for its potential medicinal properties, including anti-cancer and anti-inflammatory effects. As a result, it has garnered interest in the pharmaceutical industry for its potential use as a therapeutic agent.

InChI:InChI=1/C12H14N2O2/c1-3-16-12(15)11-7(2)14-10-6-8(13)4-5-9(10)11/h4-6,14H,3,13H2,1-2H3

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Downstream Products

• 102308-53-2 6-amino-2-methylindole 

Relevant articles and documents

Aromatic heterocycle-containing 2, 4-diarylaminopyrimidine derivative as well as preparation and application of 2, 4-diarylaminopyrimidine derivative

The invention relates to an aromatic heterocycle-containing 2, 4-diarylaminopyrimidine derivative represented by a general formula I, an optical isomer, a pharmaceutically acceptable salt, a solvate or a prodrug thereof, preparation methods of the aromatic heterocycle-containing 2, 4-diarylaminopyrimidine derivative and the optical isomer, the pharmaceutically acceptable salt, the solvate or the prodrug, and a pharmaceutical composition using the compound represented by the general formula I as an active component, wherein substituents R1, R2, R3, R4, R5, R6, X, Y and Z have meanings given inthe specification. The invention also relates to the compound shown in the general formula I, which has strong ALK and ROS1 kinase inhibition effects, and also relates to application of the compound and the optical isomer and pharmaceutically acceptable salt thereof in preparation of drugs for treatment and/or prevention of diseases caused by ALK and ROS1 abnormal expression, and application of the compound in preparation of drugs for prevention of diseases caused by ALK and ROS1 abnormal expression. Use in particular in the preparation of a medicament for treatment and/or for preventing cancer