5465-68-9

Basic information

• Product Name: 2-(2,4-Dinitrophenyl)acetoacetic acid ethyl ester
• Synonyms: 2-(2,4-Dinitrophenyl)acetoacetic acid ethyl ester
• CAS NO: 5465-68-9
• Molecular Formula: C₁₂H₁₂N₂O₇
• Molecular Weight: 296.2329
• Mol File: 5465-68-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 443.1°Cat760mmHg
• Flash Point: 194.6°C
• Appearance: /
• Density: 1.388g/cm³
• Vapor Pressure: 4.76E-08mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 2-(2,4-Dinitrophenyl)acetoacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Dinitrophenyl)acetoacetic acid ethyl ester(5465-68-9)
• EPA Substance Registry System: 2-(2,4-Dinitrophenyl)acetoacetic acid ethyl ester(5465-68-9)

Safety Data

• Hazardous Substances Data: 5465-68-9(Hazardous Substances Data)

Usage

Chemical structure

2-(2,4-Dinitrophenyl)acetoacetic acid ethyl ester is an ethyl ester derivative of 2-(2,4-dinitrophenyl)acetoacetic acid.

Usage

It is commonly used in the synthesis of pharmaceuticals and dyes.

Physical properties

It is known for its strong yellow color.

Analytical applications

It is often used as a reagent to detect the presence of various functional groups.

Synthesis of chiral molecules

It is used in the synthesis of chiral molecules.

Precursors

It serves as a precursor for the production of various drugs and biologically active compounds.

Versatility

It is a versatile compound with a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C12H12N2O7/c1-3-21-12(16)11(7(2)15)9-5-4-8(13(17)18)6-10(9)14(19)20/h4-6,11H,3H2,1-2H3

Upstream product

• 2486-07-9 2,4-dinitrophenyl phenyl ether 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 742-25-6 2,4-dinitrophenyl 4-methylbenzenesulfonate 
• 584-48-5 2,4-dinitrobromobenzene 
• 141-97-9 ethyl acetoacetate 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 64-17-5 ethanol 
• 71-43-2 benzene 
• 70-34-8 2,4-Dinitrofluorobenzene 

Downstream Products

• 124-38-9 carbon dioxide 
• 2200-86-4 1-(2,4-dinitrophenyl)propan-2-one 
• 643-43-6 (2,4-dinitro-phenyl)-acetic acid 
• 60-35-5 acetamide 
• 132515-38-9 N-(2-methyl-indol-6-yl)-benzamide 
• 102308-53-2 6-amino-2-methylindole 
• 762-84-5 N-tert-butylacetamide 
• 1772-43-6 2,4,4-trimethyl oxazoline 
• 1569-96-6 N-(1-hydroxy-2-methylpropan-2-yl)acetamide 
• 68084-17-3 α-(2,4-dinitrophenyl)ethyl acetate 
• 64-17-5 ethanol 

Relevant articles and documents

Aromatic heterocycle-containing 2, 4-diarylaminopyrimidine derivative as well as preparation and application of 2, 4-diarylaminopyrimidine derivative

The invention relates to an aromatic heterocycle-containing 2, 4-diarylaminopyrimidine derivative represented by a general formula I, an optical isomer, a pharmaceutically acceptable salt, a solvate or a prodrug thereof, preparation methods of the aromatic heterocycle-containing 2, 4-diarylaminopyrimidine derivative and the optical isomer, the pharmaceutically acceptable salt, the solvate or the prodrug, and a pharmaceutical composition using the compound represented by the general formula I as an active component, wherein substituents R1, R2, R3, R4, R5, R6, X, Y and Z have meanings given inthe specification. The invention also relates to the compound shown in the general formula I, which has strong ALK and ROS1 kinase inhibition effects, and also relates to application of the compound and the optical isomer and pharmaceutically acceptable salt thereof in preparation of drugs for treatment and/or prevention of diseases caused by ALK and ROS1 abnormal expression, and application of the compound in preparation of drugs for prevention of diseases caused by ALK and ROS1 abnormal expression. Use in particular in the preparation of a medicament for treatment and/or for preventing cancer

Biaryl Formation in the Copper(I) Mediated Arylation of Stable Enolate Anions with o-Halogenonitrobenzenes

o-Bromo- and o-iodonitrobenzenes react with stable enolate anions in hot DMF in the presence of copper(I) iodide, to afford not the expected arylation products but the coupling products, 2,2'-dinitrobiphenyls.