102308-53-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indol-6-amine,2-methyl-(9CI) is used as a key intermediate in the synthesis of aza-podophyllotoxin derivatives, which are a class of compounds with significant potential in cancer treatment. These derivatives have been found to exhibit stronger growth inhibition activity in various cancer cell lines, including Zr-75-1, MCF7, KB, Gurav, DWD, Colo-205, A-549, and Hop62. 1H-Indol-6-amine,2-methyl-(9CI)'s role in the development of these derivatives highlights its importance in the pharmaceutical industry for the creation of novel and effective cancer therapies.

Upstream product

• 3484-23-9 2-methyl-6-nitro-1H-indole 
• 7647-01-0 hydrogenchloride 
• 4993-93-5 4-nitro-1H-indole-2-carboxylic acid ethyl ester 
• 134747-25-4 ethyl 2-[2-(3-nitrophenyl)hydrazinylidene]propanoate 
• 1056933-72-2 (E)-ethyl 2-(2-(3-nitrophenyl)hydrazono)propanoate 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 5465-68-9 2-(2,4-dinitrophenyl)-3-oxobutyric acid ethyl ester 
• 584-48-5 2,4-dinitrobromobenzene 
• 945655-37-8 6-amino-2-methyl-1H-indole-3-carboxylic acid ethyl ester 
• 7664-93-9 sulfuric acid 

Downstream Products

• 132515-38-9 N-(2-methyl-indol-6-yl)-benzamide 
• 1186120-97-7 C₁₇H₁₄N₄O 

Relevant academic research and scientific papers

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Process for producing indole compound

There is provided a novel process for producing an indole derivative which comprises cyclizing 2-nitrobenzylcarbony compound in the presence of a catalyst comprising a Group VIII metal of the Periodic Table, characterized by conducting the cyclization in a gas atmosphere containing carbon monoxide. The process enables an indole compound to be selectively produced in a high yield from 2-nitrobenzylcarbonyl compound, and hardly yields an indoline compound as a reduction by-product that has been a problem in the catalytic hydrogenation method employing a noble metal catalyst. The indole derivative produced by the present process is useful for various fine chemical intermediates including compounds and physiologically active substances such as pharmaceuticals and agrochemicals.

Process for dyeing keratinous fibres combining isatin or its derivatives with an aminoindole or an aminoindoline, and compositions used

The invention relates to a process for dyeing keratinous fibres, comprising the simultaneous or sequential application of a composition (A) containing a compound of formula (I): STR1 in which: R1 denotes hydrogen, alkyl, acetyl, benzoyl, phenyl or C1 -C4 carboxyalyl (sic); R2 and R3 denote hydrogen, alkyl, alkoxy, hydroxyalkyl, amino, halogen, nitro, alkylphenyl, phenyl, alkylamino, hydroxyalkylamino; and a composition (B) containing at least one compound of formula (II): STR2 in which: R4 and R6 denote hydrogen, alkyl; R5 denotes hydrogen, alkyl, COOR' where R' is hydrogen or alkyl; Z1 represents hydrogen, halogen, alkyl, alkoxy or hydroxyl; Z2 represents hydrogen or alkyl or a compound of formula (III): STR3 in which: R7 and R8 denote hydrogen or alkyl; X1 and X2 represent hydrogen or an NH2 radical; R9 denotes hydrogen, alkyl, alkoxy; as well as the compositions used.

Methods for dyeing keratinous fibres with aminoindoles, compositions and devices for use

Method for dyeing keratinous fibres, in particular human keratinous fibres, such as hair, characterized in that a composition (A) containing, in a medium appropriate for dyeing, at least one aminoindole corresponding to the formula: STR1 in which: R1 and R3, independently of one another, represent a hydrogen atom or a C1 -C4 alkyl group; R2 denotes hydrogen or a C1 -C4 alkyl group or COOR', R' being a hydrogen atom or a C1 -C4 alkyl group; R4 represents a hydrogen atom or a C1 -C4 alkyl, C1 -C4 hydroxyalkyl or C2 -C4 polyhydroxyalkyl group; Z1 represents a hydrogen or halogen atom or a C1 -C4 alkyl group or OR; R being a hydrogen atom or a C1 -C4 alkyl group; and Z2 represents a hydrogen atom or a C1 -C4 alkyl group; and its salts is applied to said fibres, the colour being developed with the aid of an oxidizing system.