945684-67-3

Upstream product

• 945684-60-6 (E)-3-(diethoxyphosphoryloxy)-1-(dimethylphenylsilyl)-1-propene 
• 557-20-0 diethylzinc 
• 1192353-96-0 C₁₅H₂₅O₄PSi 
• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 
• 88761-82-4 methyl β-(E)-2-dimethylphenylsilylacrylate 

Downstream Products

• 945684-63-9 methyl (S)-(-)-4-(dimethylphenylsilyl)-hex-2(E)-enoate 

Relevant academic research and scientific papers

Asymmetric Conjugate Addition of Grignard Reagents to 3-Silyl Unsaturated Esters for the Facile Preparation of Enantioenriched β-Silylcarbonyl Compounds and Allylic Silanes

A highly enantioselective conjugate addition of Grignard reagents to 3-silyl unsaturated esters to deliver synthetically useful chiral β-silylcarbonyl compounds was developed. The synthetic value of this methodology was further illustrated by the synthesis of enantioenriched β-hydroxyl esters and the facile access granted to various α-chiral allylic silanes. A plethora of diastereoselective transformations of β-silylenolates were also investigated and afforded manifold organosilanes that contained contiguous stereogenic centers with excellent enantioselectivity.

Enantioselective copper-catalyzed allylic substitution reaction with aminohydroxyphosphine ligand

A proline-derived aminohydroxyphosphine ligand induced excellent regio- and enantiose-lectivities (SN2′: SN2>94:6, 94-97% ee) in the copper-catalyzed substitution reaction of cinnamyl phosphates with Et2Zn. A computational

Stereogenic-at-metal Zn- and Al-based N-Heterocyclic Carbene (NHC) complexes as bifunctional catalysts in Cu-free enantioselective allylic alkylations

Investigations detailed herein demonstrate the ability of chiral bidentate N-heterocyclic carbenes to promote directly - without the need for a Cu salt - site- and enantioselective C-C bond forming reactions. Within this context, catalytic allylic alkylat

Enantioselective synthesis of allylsilanes bearing tertiary and quaternary si-substituted carbons through Cu-catalyzed allylic alkylations with alkylzinc and arylzinc reagents

All sorts of allylsilanes including, for the first time, those that contain a Si-bonded quaternary carbon, were synthesized through efficient and highly enantioselective Cu-catalyzed asymmetric allylic alkylations. Reactions may involve dialkyl- as well as diarylzinc reagents and are promoted by various chiral N-heterocyclic carbene complexes.