94573-86-1Relevant academic research and scientific papers
Similarity and Differences in the Regioselectivities of Thermal and Acid-Catalyzed van Alphen–Hüttel Rearrangements in the Series of 3,3-Diphenyl-3H-pyrazoles Containing Electron-Withdrawing Substituents on C4 and C5
Vasin,Razin,Bezrukova
, p. 1045 - 1054 (2018/09/11)
3,3-Diphenyl-3H-pyrazoles containing an electron-withdrawing substituent in the 5-position undergo van Alphen–Hüttel rearrangement with migration of one phenyl group to C4 on heating in an aprotic solvent (benzene, toluene), as well as on keepi
One-pot conversion of β-aminocrotononitrile to secondary enaminonitriles including chiral ones - Application to synthesis
Chatterjee,Mishra,Dutta Chowdhury,Mahalanabis, Kumar K.
, p. 1164 - 1170 (2007/10/03)
A highly efficient one-pot conversion of β-aminocrotononitrile to secondary enaminonitriles including chiral ones is described. In contrast to β-aminocrotononitrile, some of these N-substituted β-enaminonitriles on reacting with acid chlorides show a unique preference for C-terminal selection allowing preparation of pyrazoles without separation of regioisomers. In addition, use of secondary enaminonitriles also provided access to pyrazoles that are not obtainable with primary enaminonitriles owing to an exclusive preference for N-terminal selection.
On the regiospecificity of 3,5-disubstituted pyrazoles derived from C-acylated-β-enaminonitriles and esters
Mukherjee,Mishra,Chatterjee,Sarkar,Dutta Chowdhury,Mahalanabis, Kumar K.
, p. 2333 - 2337 (2007/10/03)
Regiospecificity of 3,5-disubstituted pyrazoles derived from reaction of phenylhydrazine with α-acyl-β-aminocrotononitriles and esters is primarily deduced on the basis of spectral analyses. The present work provides direct and unambiguous evidences in su
