945840-69-7

Usage

Uses

Used in Pharmaceutical Development:
1H-Pyrrolo[2,3-c]pyridine, 7-bromo-5-chlorois used as a potential pharmaceutical agent for the development of novel therapeutics. Its unique structure and potential pharmacological properties make it a promising candidate for various therapeutic indications.
Used in Organic Synthesis:
1H-Pyrrolo[2,3-c]pyridine, 7-bromo-5-chlorois used as a building block in organic synthesis for the creation of diverse molecular structures with potential biological activities. Its unique heterocyclic structure allows for the development of new compounds with potential applications in various fields.
Further research and investigation into the properties and potential applications of 1H-Pyrrolo[2,3-c]pyridine, 7-bromo-5-chloroare warranted to fully understand its scientific and commercial potential.

Upstream product

• 91678-23-8 2-bromo-6-chloro-3-nitropyridine 
• 1826-67-1 vinyl magnesium bromide 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 

Relevant academic research and scientific papers

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors

The epigenetic regulator CBP/P300 presents a novel therapeutic target for oncology. Previously, we disclosed the development of potent and selective CBP bromodomain inhibitors by first identifying pharmacophores that bind the KAc region and then building into the LPF shelf. Herein, we report the "hybridization" of a variety of KAc-binding fragments with a tetrahydroquinoline scaffold that makes optimal interactions with the LPF shelf, imparting enhanced potency and selectivity to the hybridized ligand. To demonstrate the utility of our hybridization approach, two analogues containing unique Asn binders and the optimized tetrahydroquinoline moiety were rapidly optimized to yield single-digit nanomolar inhibitors of CBP with exquisite selectivity over BRD4(1) and the broader bromodomain family.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

Heterobicyclic amide compounds

Compounds of formula I processes for their preparation and pharmaceutical compositions comprising them.