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Upstream product

• 3288-13-9 diethyl (4-methylphenyl)thiocarbamamoylmalonate 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 506436-27-7 ethyl 3-(4-methylphenyl)amino-5-oxo-2,5-dihydroisoxazole-4-carboxylate 

Relevant academic research and scientific papers

Synthesis and single crystal X-ray structure of ethyl 2-(1,3-benzoxazol-2- yl)-5-oxo-3-(4-toluidino)-2,5-dihydro-4-isoxazolecarboxylate

Ethyl 5-oxo-3-(4-toluidino)-2,5-dihydro-4-isoxazolecarboxylate was prepared from the reaction of diethyl 2-(4-toluidinocarbothioyl)malonate with hydroxylamine. Its reaction with 2-chlorobenzoxazole gave the corresponding N-substituted isoxazolone. The str

The facile synthesis of N-aryl isoxazolones as DNA intercalators under solvent-free conditions using microwave irradiation

The reaction of chloroheterocycles with some isoxazolones under microwave irradiation and under solvent-free conditions to give the corresponding mono isoxazolinyl derivatives is reported. The main advantages of this method are: (i) elimination of the nitrogen gas (N2), (ii) solvent-free conditions, (iii) microwave irradiation, (iv) avoiding the use of silica gel for purification of the products, and (v) higher and shorter reaction times. These compounds have potential applications as DNA intercalators.