506436-27-7

Upstream product

• 105-53-3 diethyl malonate 
• 64-17-5 ethanol 
• 3288-13-9 diethyl (4-methylphenyl)thiocarbamamoylmalonate 
• 996-82-7 sodium diethylmalonate 

Downstream Products

• 506436-33-5 ethyl 3-(4-methylphenyl)amino-2-(5-nitropyridin-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 945917-86-2 ethyl 2-(benzoxazol-2-yl)-3-(4-methylphenylamino)-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 1271133-91-5 ethyl 2-(p-tolylamino)imidazo[1,2-a]pyrimidine-3-carboxylate 
• 948905-03-1 ethyl 2-(benzothiazol-2-yl)-3-(4-methylphenyl)amino-5-oxo-2, 5-dihydroisoxazole-4-carboxylate 
• 1334232-63-1 8-methyl-3-(4-methylphenyl)-1H-azeto[2',1':2,3]pyrimido[4,5-b]quinoline-1,4(3H)-dione 
• 1334232-58-4 7-methyl-3-(4-methylphenyl)-1H-azeto[2',1':2,3]pyrimido[4,5-b]quinoline-1,4(3H)-dione 
• 1334232-53-9 3-(4-methylphenyl)-1H-azeto[2',1':2,3]pyrimido[4,5-b]quinoline-1,4(3H)-dione 
• 1271133-61-9 ethyl 5-oxo-2-(pyrimidin-2-yl)-3-(p-tolylamino)-2,5-dihydroisoxazole-4-carboxylate 

Relevant academic research and scientific papers

Rearrangements of 2-pyridyl-3-arylaminoisoxazol-5(2H)-ones to imidazo[1,2-a]pyridines under flash-vacuum-pyrolysis

2-Pyridyl-3-arylaminoisoxazol-5(2H)-ones, rearranged under flash-vacuum-pyrolysis (FVP) conditions accompanied by elimination of carbon dioxide to give imidazo[1,2-a]pyridines in high to excellent yields (85-95 %).

The facile synthesis of N-aryl isoxazolones as DNA intercalators under solvent-free conditions using microwave irradiation

The reaction of chloroheterocycles with some isoxazolones under microwave irradiation and under solvent-free conditions to give the corresponding mono isoxazolinyl derivatives is reported. The main advantages of this method are: (i) elimination of the nitrogen gas (N2), (ii) solvent-free conditions, (iii) microwave irradiation, (iv) avoiding the use of silica gel for purification of the products, and (v) higher and shorter reaction times. These compounds have potential applications as DNA intercalators.

Ethyl 5-oxo-3-arylamino-2,5-dihydroisoxazole-4-carboxylates as sources of imidazopyrimidine and aminoindole derivatives

The reaction of ethyl 5-oxo-3-arylamino-2,5-dihydroisoxazole-4-carboxylates with 2-chloropyrimidine and 2-chlorobenzoxazole gave the corresponding isoxazolones with pyrimidine and benzoxazole rings substituted on N-2. Their rearrangements with triethylamine in ethanol produced the corresponding imidazopyrimidine and aminoindole derivatives, respectively, through intramolecular cyclisation. TUeBITAK.

Synthesis and single crystal X-ray structure of ethyl 2-(1,3-benzoxazol-2- yl)-5-oxo-3-(4-toluidino)-2,5-dihydro-4-isoxazolecarboxylate

Ethyl 5-oxo-3-(4-toluidino)-2,5-dihydro-4-isoxazolecarboxylate was prepared from the reaction of diethyl 2-(4-toluidinocarbothioyl)malonate with hydroxylamine. Its reaction with 2-chlorobenzoxazole gave the corresponding N-substituted isoxazolone. The str

2-Aryl-3-arylaminoisoxazol-5(2H)-ones as sources of indoles and imidazo[1,2-a]pyridines

2-Aryl-3-arylaminoisoxazol-5(2H)-ones undergo solvolysis to form 1,3-dipoles that undergo intramolecular cyclisation to form either imidazopyridines or indoles. The mode of cyclisation is controlled by the electronegativity of the aryl substituents.