945933-49-3

Basic information

• Product Name: 3-(2-(2-(bromomethyl)thiazol-4-yl)ethynyl)-5-fluorobenzonitrile
• Synonyms: 3-(2-(2-(bromomethyl)thiazol-4-yl)ethynyl)-5-fluorobenzonitrile
• CAS NO: 945933-49-3
• Molecular Weight: 321.172
• Mol File: 945933-49-3.mol

Chemical Properties

• CAS DataBase Reference: 3-(2-(2-(bromomethyl)thiazol-4-yl)ethynyl)-5-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-(2-(bromomethyl)thiazol-4-yl)ethynyl)-5-fluorobenzonitrile(945933-49-3)
• EPA Substance Registry System: 3-(2-(2-(bromomethyl)thiazol-4-yl)ethynyl)-5-fluorobenzonitrile(945933-49-3)

Safety Data

• Hazardous Substances Data: 945933-49-3(Hazardous Substances Data)

Upstream product

• 179898-34-1 3-bromo-5-fluorobenzonitrile 
• 945933-47-1 5-fluoro-3-(2-(2-(tert-butyldimethylsilyloxymethyl)thiazol-4-yl)ethynyl)benzonitrile 
• 872122-56-0 3-ethynyl-5-fluorobenzonitrile 
• 914948-32-6 3-fluoro-5-(2-(trimethylsilyl)ethynyl)benzonitrile 
• 945933-48-2 3-fluoro-5-(2-(2-(hydroxymethyl)thiazol-4-yl)ethynyl)benzonitrile 

Relevant articles and documents

A short and efficient synthesis of 3-{2-[2-(bromomethyl)thiazol-4-yl]- ethynyl}-5-fluorobenzonitrile: A precursor for PET radioligand [ 18F]SP203

An improved synthesis of 3-{2-[2-(bromomethyl)thiazol-4-yl]ethynyl}-5- fluorobenzonitrile, a precursor for PET radioligand [18F]SP203, is described, wherein a new synthon was employed for Sonogashira coupling with 3-bromo-5-fluorobenzonitrile.

Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2- (fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography

2-Fluoromethyl analogs of (3-[(2-methyl-1,3-thiazol-4yl)ethynyl]pyridine) were synthesized as potential ligands for metabotropic glutamate subtype-5 receptors (mGluR5s). One of these, namely, 3-fluoro-5-(2-(2-(fluoromethyl) thiazol-4-yl)ethynyl)benzonitri