Synthesis p. 1979 - 1982 (2009)
Update date:2022-08-04
Topics:
Gopinathan, Madathil B.
Jin, Chunyang
Rehder, Kenneth S.
An improved synthesis of 3-{2-[2-(bromomethyl)thiazol-4-yl]ethynyl}-5- fluorobenzonitrile, a precursor for PET radioligand [18F]SP203, is described, wherein a new synthon was employed for Sonogashira coupling with 3-bromo-5-fluorobenzonitrile.
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Doi:10.1271/bbb1961.48.3185
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