946077-16-3Relevant academic research and scientific papers
Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors
Kode, Jyoti,Kovvuri, Jeshma,Nagaraju, Burri,Jadhav, Shailesh,Barkume, Madan,Sen, Subrata,Kasinathan, Nirmal Kumar,Chaudhari, Pradip,Mohanty, Bhabani Shankar,Gour, Jitendra,Sigalapalli, Dilep Kumar,Ganesh Kumar,Pradhan, Trupti,Banerjee, Manisha,Kamal, Ahmed
supporting information, (2020/11/17)
A library of new phenstatin based indole linked chalcone compounds (9a-z and 9aa-ad) were designed and synthesized. Of these, compound 9a with 1-methyl, 2- and 3-methoxy substituents in the aromatic ring was efficacious against the human oral cancer cell
New (3-(1: H -benzo [d] imidazol-2-yl))/(3-(3 H -imidazo[4,5- b] pyridin-2-yl))-(1 H -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors
Mullagiri, Kishore,Nayak, V. Lakshma,Sunkari, Satish,Mani, Geeta Sai,Guggilapu, Sravanthi Devi,Nagaraju, Burri,Alarifi, Abdullah,Kamal, Ahmed
, p. 275 - 281 (2018/03/08)
A series of new (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates 4-6(a-i) were synthesized and evaluated for their antiproliferative activity on selected human cancer cell lines
4- And 5-aroylindoles as novel classes of potent antitubulin agents
Liou, Jing-Ping,Wu, Chang-Ying,Hsieh, Hsing-Pang,Chang, Chi-Yen,Chen, Chi-Ming,Kuo, Ching-Chuan,Chang, Jang-Yang
, p. 4548 - 4552 (2008/02/13)
A novel series of 4- and 5-aroylindole derivatives was prepared and evaluated for antitumor activity. Several compounds showed excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 13,14,15, and 18, with IC50 v
Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure-activity relationships
Hu, Laixing,Jiang, Jian-dong,Qu, Jinrong,Li, Yan,Jin, Jie,Li, Zhuo-rong,Boykin, David W.
, p. 3613 - 3617 (2008/02/05)
We report the synthesis, antiproliferative activity, and SAR of novel heterocyclic ketones derived from carbazole sulfonamides. Most of the heterocyclic ketones showed strong cytotoxicities. (N-1-Methylindole-5-yl)-(3,4,5-trimethoxyphenyl)-methanone 8b gave the most potent cytotoxicity (9.2-26 nM) against seven human tumor cell lines. The mechanism of action of the heterocyclic ketones appears to involve targeting of tubulin, similar to that of CA-4 and different from the carbazole sulfonamides.
