946077-32-3

Basic information

• Product Name: C₂₄H₃₁NO₄Si
• Synonyms: C₂₄H₃₁NO₄Si
• CAS NO: 946077-32-3
• Molecular Weight: 425.6
• Mol File: 946077-32-3.mol

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₁NO₄Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₁NO₄Si(946077-32-3)
• EPA Substance Registry System: C₂₄H₃₁NO₄Si(946077-32-3)

Safety Data

• Hazardous Substances Data: 946077-32-3(Hazardous Substances Data)

Upstream product

• 331432-91-8 5-bromo-1-(tert-butyldimethylsilyl)-1H-indole 
• 10075-50-0 5-bromo-1H-indole 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1196-69-6 1H-indole-5-carboxaldehyde 
• 946077-36-7 C₁₅H₂₁NOSi 
• 946077-37-8 (1-(tert-butyldimethylsilyl)-1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanol 

Downstream Products

• 946077-16-3 (1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone 

Relevant articles and documents

New (3-(1: H -benzo [d] imidazol-2-yl))/(3-(3 H -imidazo[4,5- b] pyridin-2-yl))-(1 H -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors

A series of new (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates 4-6(a-i) were synthesized and evaluated for their antiproliferative activity on selected human cancer cell lines

Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure-activity relationships

We report the synthesis, antiproliferative activity, and SAR of novel heterocyclic ketones derived from carbazole sulfonamides. Most of the heterocyclic ketones showed strong cytotoxicities. (N-1-Methylindole-5-yl)-(3,4,5-trimethoxyphenyl)-methanone 8b gave the most potent cytotoxicity (9.2-26 nM) against seven human tumor cell lines. The mechanism of action of the heterocyclic ketones appears to involve targeting of tubulin, similar to that of CA-4 and different from the carbazole sulfonamides.