946132-14-5Relevant articles and documents
26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D 3 compounds selectively active on intestine
Chiellini, Grazia,Grzywacz, Pawel,Plum, Lori A.,Clagett-Dame, Margaret,Deluca, Hector F.
, p. 27 - 38 (2014/03/21)
Six new analogs of 2-methylene-19-nor-1α,25-dihydroxyvitamin D 3, 6-7 and 8a,b-9a,b, have been synthesized. All compounds are characterized by a trans double bond located in the side chain between C-22 and C-23. While compounds 6 and 7 possess
Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription
Grzywacz, Pawel,Chiellini, Grazia,Plum, Lori A.,Clagett-Dame, Margaret,Deluca, Hector F.
, p. 8642 - 8649 (2011/03/20)
Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D3 (5-16) were prepared by convergent syntheses, employing the Wittig Horner reaction. The necessary Grundmann type ketones (45-48), possessing fixed configurations of the hydroxyl group at
VITAMIN D ANALOG - NEL, METHODS AND USES THEREOF
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Page/Page column 9; 12, (2008/06/13)
Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 ca