94635-26-4

Upstream product

• 94635-25-3 ethyl cyano-[1-(p-methoxyphenyl)-4-piperidinylidene]acetate 
• 56525-68-9 3,3'-(4-methoxy-phenylimino)-di-propionic acid diethyl ester 
• 104-94-9 4-methoxy-aniline 
• 94635-24-2 1-(4-methoxyphenyl)piperidin-4-one 
• 94635-23-1 ethyl 1-(p-methoxyphenyl)-4-oxo-3-piperidinecarboxylate 

Downstream Products

• 94635-22-0 2,4-diamino-6-chloro-5-[1-(4-methoxyphenyl)-4-piperidinyl]pyrimidine 
• 94635-27-5 2,6-Diamino-5-[1-(4-methoxy-phenyl)-piperidin-4-yl]-pyrimidin-4-ol 

Relevant academic research and scientific papers

5-(N-Arylnortropan-3-yl)- and 5-(N-Arylpiperidin-4-yl)-2,4-diaminopyrimidines. Novel Inhibitors of Dihydrofolate Reductase

Based on a computer-assisted analysis of the three-dimensional structure of the binary complex of E.coli dihydrofolate reductase (DHFR) with methotrexate, 5-(N-arylnortropan-3-yl)- and 5-(N-arylpiperidin-4-yl)-2,4-diaminopyrimidines 2 and 4 were designed