94635-24-2Relevant academic research and scientific papers
NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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, (2016/07/27)
The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.
NOVEL PIPERIDINE DERIVATIVE
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Page/Page column 117, (2008/06/13)
Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmac
An improved synthesis of N-aryl and N-heteroaryl substituted piperidones
Sch?n, Uwe,Messinger, Josef,Buckendahl,Prabhu,Konda
, p. 2519 - 2525 (2008/02/02)
An efficient Pd(0)-catalyzed protocol for the rapid and efficient preparation of N-aryl and N-heteroaryl substituted piperidones is described. The two step syntheses proceed with an overall yield of 50-70% using X-Phos as optimal ligand for the Pd(0)-cata
Stepwise versus direct long-range charge separation in molecular triads
Willemse,Piet,Warman,Hartl,Verhoeven,Brouwer
, p. 3721 - 3730 (2007/10/03)
Trifunctional electron donor - donor - acceptor molecules are described in which photoinduced charge separation, D2 - D1 - A* → D2 - D1+ - A- , is followed by a charge migration step D
Synthesis and exploratory photophysical investigation of donor-bridge-acceptor systems derived from N-substituted 4-piperidones
Scherer, T.,Hielkema, W.,Krijnen, B.,Hermant, R. M.,Eijckelhoff, C.,et al.
, p. 535 - 548 (2007/10/02)
We report a two-step synthesis for N-aryl- and N-alkyl-substituted 4-piperidones, in which the N substituent can easily be varied.A number of intramolecular donor-acceptor systems was synthesized from these piperidones by conversion of the carbonyl functionality.The influence of the N-aryl donor on the electronic absorption and fluorescence spectra was investigated systematically.It was concluded that some systems can be used as efficient fluorescent probes with a high sensitivity for solvent polarity.
5-(N-Arylnortropan-3-yl)- and 5-(N-Arylpiperidin-4-yl)-2,4-diaminopyrimidines. Novel Inhibitors of Dihydrofolate Reductase
Maag, Hans,Locher, Rita,Daly, John J.,Kompis, Ivan
, p. 887 - 897 (2007/10/02)
Based on a computer-assisted analysis of the three-dimensional structure of the binary complex of E.coli dihydrofolate reductase (DHFR) with methotrexate, 5-(N-arylnortropan-3-yl)- and 5-(N-arylpiperidin-4-yl)-2,4-diaminopyrimidines 2 and 4 were designed
2,4-diamino-[4-piperidinyl]pyrimidines useful as antibacterial agents, antimalarial agents, antitumors agents
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, (2008/06/13)
The pyrimidine derivatives of formula I STR1 wherein R1 is naphthyl, substituted naphthyl or substituted phenyl; R2 is hydrogen or lower alkoxy; and A is an optionally present ethylene or 1,3-propylene, and wherein the diaminopyridin
