946438-16-0

Basic information

• Product Name: methyl 1-(3-phenylpropanoyl)pyrrolidine-2-carboxylate
• Synonyms: methyl 1-(3-phenylpropanoyl)pyrrolidine-2-carboxylate
• CAS NO: 946438-16-0
• Molecular Weight: 261.321
• Mol File: 946438-16-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 1-(3-phenylpropanoyl)pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(3-phenylpropanoyl)pyrrolidine-2-carboxylate(946438-16-0)
• EPA Substance Registry System: methyl 1-(3-phenylpropanoyl)pyrrolidine-2-carboxylate(946438-16-0)

Safety Data

• Hazardous Substances Data: 946438-16-0(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 85665-59-4 methyl 1-(chlorocarbonyl)pyrrolidine-2-carboxylate 
• 2133-40-6 methyl pyrrolidine-2-carboxylate hydrochloride 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 43041-12-9 methyl pyrrolidine-2-carboxylate 

Relevant articles and documents

Nickel-Catalyzed Reduction of Secondary and Tertiary Amides

The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.

One-pot amidation of olefins through Pd-catalyzed coupling of alkylboranes and carbamoyl chlorides

(Chemical Equation Presented) A one-pot synthesis of C1- elongated amides starting from olefins and carbamoyl chlorides has been developed. Alkyl-boranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs2CO3.