946522-94-7Relevant articles and documents
From tyrosine to glycine: Synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor
Romagnoli, Romeo,Baraldi, Pier Giovanni,Carrion, Maria Dora,Cara, Carlota Lopez,Preti, Delia,Cruz-Lopez, Olga,Tabrizi, Mojgan Aghazadeh,Moorman, Allan R.,Gessi, Stefania,Fogli, Eleonora,Sacchetto, Valeria,Borea, Pier Andrea
, p. 3706 - 3715 (2008/02/09)
The characterization of the native and recombinant P2X7 receptor continues to be hindered by the lack of specific and subtype-selective antagonists with a "druglike" profile. However, a tyrosine derivative named KN-62 exhibits selective P2Xsub