946532-50-9Relevant academic research and scientific papers
Iodocarbocyclization reaction of β-ketoesters and alkynes
Barluenga, Jose,Palomas, David,Rubio, Eduardo,Gonzalez, Jose M.
, p. 2823 - 2826 (2007)
Iodocyclopentenes are formed at room temperature upon straight reaction of δ-alkynyl-β-ketoesters with I2 for several hours. Cyclizations involving terminal and substituted (alkyl, aryl, Br, I) alkynes were accessed. Twelve examples with yields ranging from 20% up to 80% are reported (out of them eight cases are above 60%). These results present the first examples of the iodonium-promoted 5-endo-dig carbocyclization of active methyne substrates onto alkynes.
