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phenyl (R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

946589-86-2

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946589-86-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 946589-86-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,6,5,8 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 946589-86:
(8*9)+(7*4)+(6*6)+(5*5)+(4*8)+(3*9)+(2*8)+(1*6)=242
242 % 10 = 2
So 946589-86-2 is a valid CAS Registry Number.

946589-86-2Downstream Products

946589-86-2Relevant academic research and scientific papers

Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis

Santella, Joseph B.,Gardner, Daniel S.,Duncia, John V.,Wu, Hong,Dhar, Murali,Cavallaro, Cullen,Tebben, Andrew J.,Carter, Percy H.,Barrish, Joel C.,Yarde, Melissa,Briceno, Stephanie W.,Cvijic, Mary Ellen,Grafstrom, R. Robert,Liu, Richard,Patel, Sima R.,Watson, Andrew J.,Yang, Guchen,Rose, Anne V.,Vickery, Rodney D.,Caceres-Cortes, Janet,Caporuscio, Christian,Camac, Daniel M.,Khan, Javed A.,An, Yongmi,Foster, William R.,Davies, Paul,Hynes, John

, p. 7550 - 7564 (2015/02/18)

High-affinity, functionally potent, urea-based antagonists of CCR1 have been discovered. Modulation of PXR transactivation has revealed the selective and orally bioavailable CCR1 antagonist BMS-817399 (29), which entered clinical trials for the treatment of rheumatoid arthritis.

PRODRUGS OF A PIPERIDINYL DERIVATIVE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

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, (2011/04/24)

The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well a

PIPERIDINYL DERIVATIVE AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY

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, (2010/01/30)

The present application describes the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune

PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

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Page/Page column 297, (2008/06/13)

The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseas

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