94695-49-5

Basic information

• Product Name: diethyl (2,3,4,5-tetrafluorobenzoyl)malonate
• Synonyms: diethyl (2,3,4,5-tetrafluorobenzoyl)malonate
• CAS NO: 94695-49-5
• Molecular Weight: 336.24
• Mol File: 94695-49-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: diethyl (2,3,4,5-tetrafluorobenzoyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (2,3,4,5-tetrafluorobenzoyl)malonate(94695-49-5)
• EPA Substance Registry System: diethyl (2,3,4,5-tetrafluorobenzoyl)malonate(94695-49-5)

Safety Data

• Hazardous Substances Data: 94695-49-5(Hazardous Substances Data)

Upstream product

• 7664-93-9 sulfuric acid 
• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 
• 105-53-3 diethyl malonate 
• 2414-98-4 magnesium ethylate 

Downstream Products

• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 
• 1361000-74-9 ethyl (2Z)-3-hydroxy-3-(2,3,4,5-tetrafluorophenyl)-propyl-2-enoate 
• 122894-59-1 ethyl 4-[2-(N-ethoxycarbonyl-N-methylaminomethyl)morpholino]-2,3,5-trifluorobenzoylacetate 
• 104600-05-7 6,8-Difluor-1,4-dihydro-7-(4-ethyl-1-piperazinyl)-4-oxo-1-phenyl-3-chinolincarbonsaeure 
• 104599-93-1 6,7,8-Trifluor-1-phenyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeure-ethylester 
• 106809-20-5 3-Phenylamino-2-(2,3,4,5-tetrafluorbenzoyl)acrylsaeure-ethylester 
• 104599-99-7 1-phenyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 
• 94695-51-9 α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate 
• 94714-58-6 ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate 
• 94695-52-0 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid 
• 94242-51-0 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 

Relevant articles and documents

Structure of diethyl (polyfluorobenzoyl)malonates and their thermal intramolecular cyclization

The reaction of the C-ethoxymagnesium derivative of diethyl malonate with polyfluorobenzoyl chlorides affords the corresponding (polyfluorobenzoyl) malonates prone to thermal cyclization into coumarin derivatives. The compounds obtained are inherent in ke

AN IMPROVED PROCESS FOR THE PREPARATION OF LEVOFLOXACIN HEMIHYDRATE

The present invention relates to an improved process for preparation of Levofloxacin hemihydrate having single individual impurity not more than 0.1% and free from particulate matter and from the other enantiomer (R-form) which comprises dissolving levofloxacin technical grade in aqueous alkaline solution, treating the resulting solution with activated carbon at room temperature, removing the undissolved particulate matter filtration, bringing the pH of the aqueous alkaline levofloxacin solution to neutral using dilute mineral acid, removing the precipitated particulate matter by filtration, acidifying the resulting solution, treating the acidified solution with activated carbon at room temperature, filtering the undissolved particulate matter by filtration, neutralizing the acidic solution, filtering again to remove any particulate matter present and, extracting the resulting product with chlorinated solvent and concentrating under vacuum using aqueous tetrahydrofuran or in admixture with other organic solvents to get highly pure levofloxacin hemihydrate having single individual impurity is less than 0.1% and fee from particulate matter and from the other enantiomer (R-form).

Cycloaracylation of Enamines, I. - Synthesis of 4-Quinolone-3-carboxylic Acids

Starting with o-halobenzoyl chlorides 4 and open-chain secondary enamines 5, a new synthesis of 4-quinolone-3-carboxylic acids 12 is described.The reaction of 7-haloquinolone-3-carboxylic acids 12a-k with aliphatic amines 14 produces highly active antibacterial 7-aminoquinolone-3-carboxylic acids 15.The main product of the 1-cyclopropyl series, "ciprofloxacin" (15a), is being developed as a broad-spectrum chemotherapeutic agent.