947144-36-7Relevant academic research and scientific papers
Development of a practical synthesis of Toll-like receptor agonist PF-4171455: 4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5-c] pyridin-2-one
Adam, Fiona M.,Bish, Gerwyn,Calo, Frederick,Carr, Christopher L.,Castro, Nieves,Hay, Duncan,Hodgson, Paul B.,Jones, Peter,Knight, Craig J.,Paradowski, Michael,Parsons, Gemma C.,Proctor, Katie J. W.,Pryde, David C.,Rota, Filippo,Smith, Mya C.,Smith, Nicholas,Tran, Thien-Duc,Hitchin, James,Dixon, Rachel
, p. 788 - 796 (2011)
The development and implementation of a scalable process for the manufacture of the Toll-like receptor (TLR7) agonist PF-4171455 (1) is described. Initial routes used to synthesise 1 in milligram quantities were unsuitable for large-scale synthesis to pro
SPRAY DRIED FORMULATION
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Page/Page column 33-34, (2008/12/05)
Pharmaceutical compositions comprising a poorly water soluble ionizable drug, a cationic species and a dispersion polymer are disclosed, together with a process for forming the compositions. The neutral form of the drug has (i) a solubility of less than 1 mg/mL in aqueous solution at a pH between 6 and 7, (ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and (iii) an acidic pKa value of greater than 5. At least 90 wt% of the drug in the solid dispersion being in a non-crystalline form. The drug, the cationic species, and the dispersion polymer constitute at least 80 wt% of the solid dispersion.
NOVEL PHARMACEUTICALS
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Page/Page column 48, (2010/11/28)
The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.
