benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

Base Information

Chemical Name:benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester
CAS No.:947144-36-7
Molecular Formula:C₁₆H₁₃ClF₃N₃O₄
Molecular Weight:403.745
Hs Code.:

Synonyms:benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

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Chemical Property of benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

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Technology Process of benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

There total 5 articles about benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 947144-18-5
benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine

: 541-41-3
chloroformic acid ethyl ester

: 947144-36-7
benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

Guidance literature:: benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine; With potassium tert-butylate; In tetrahydrofuran; at -5 - 0 ℃; for 0.75h; Ice-salt bath;

chloroformic acid ethyl ester; In tetrahydrofuran; at 5 - 20 ℃; for 1h;

Reference yield:

: 947144-32-3
4-hydroxy-6-(trifluoromethyl)pyridin-2(1H)-one

: 947144-36-7
benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 5.5 h / 20 - 50 °C

2.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 15 h / 95 °C / Inert atmosphere; Large scale reaction

3.1: tetrahydrofuran / 22 h / Reflux; Large scale reaction

4.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 22 h / 95 °C / Inert atmosphere; Large scale reaction

5.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -10 - -8 °C / Inert atmosphere; Large scale reaction

5.2: 1.5 h / -10 - -7 °C

With P,P-dichlorophenylphosphine oxide; sulfuric acid; potassium tert-butylate; nitric acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/op200021a

Reference yield:

: 947144-26-5
4-hydroxy-3-nitro-6-trifluoromethyl-1H-pyridin-2-one

: 947144-36-7
benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 15 h / 95 °C / Inert atmosphere; Large scale reaction

2.1: tetrahydrofuran / 22 h / Reflux; Large scale reaction

3.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 22 h / 95 °C / Inert atmosphere; Large scale reaction

4.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -10 - -8 °C / Inert atmosphere; Large scale reaction

4.2: 1.5 h / -10 - -7 °C

With P,P-dichlorophenylphosphine oxide; potassium tert-butylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/op200021a