947154-87-2Relevant academic research and scientific papers
Dealkenylative Alkenylation: Formal σ-Bond Metathesis of Olefins
Kwon, Ohyun,Sadykhov, Gusein,Swain, Manisha,Wang, Ruoxi
supporting information, p. 17565 - 17571 (2020/09/01)
The dealkenylative alkenylation of alkene C(sp3)?C(sp2) bonds has been an unexplored area for C?C bond formation. Herein 64 examples of β-alkylated styrene derivatives, synthesized through the reactions of readily accessible feedstock olefins with β-nitrostyrenes by ozone/FeII-mediated radical substitutions, are reported. These reactions proceed with good efficiencies and high stereoselectivities under mild reaction conditions and tolerate an array of functional groups. Also demonstrated is the applicability of the strategy through several synthetic transformations of the products, as well as the syntheses of the natural product iso-moracin and the drug (E)-metanicotine.
Methods for the synthesis of dicarba bridges in organic compounds
-
Page/Page column 37; 38; 115; 116; 141; 142, (2015/11/17)
The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.
Highly regio- And enantioselective synthesis of g,d-unsaturated amido esters by catalytic hydrogenation of conjugated enamides
Min, Gao,Jing-jing, Meng,Hui, Lv,Xumu, Zhang
, p. 1885 - 1887 (2015/02/19)
An efficient and highly regio- and enantioselective catalytic asymmetric hydrogenation of a,γ-dienamido esters to g,d-unsaturated amido esters has been achieved using Rh/ TangPhos as the catalyst. A series of γ,δ-unsaturated amido acids were furnished in excellent yields with up to 99%ee. This effective methodology was applied in the asymmetric synthesis of key intermediate of Ramipril, an ACE inhibitor.
Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides
-
Page/Page column 69; 55; 20-21, (2010/11/28)
According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.
