947243-80-3

Upstream product

• 1124-11-4 Tetramethylpyrazine 
• 76494-51-4 Tetramethylpyrazine hydrochloride 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 79074-45-6 2-(bromomethyl)-3,5,6-trimethylpyrazine 

Downstream Products

• 947296-82-4 C₁₆H₁₉N₅O₂ 
• 1018438-87-3 4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoic acid 

Relevant academic research and scientific papers

Synthesis of novel ligustrazine derivatives as Na+/H+ exchange inhibitors

A novel series of 3,5,6-trimethylpyrazine-2-methoxy (or methylamino) substituted benzoyl-guanidine derivatives were designed and synthesized as Na+/H+ exchange (NHE) inhibitors. In this study, compounds with electron-withdrawing substituents on the benzene ring seemed to improve NHE-1 inhibitory activities. Compounds 6d, 6k, and 6l were found to be potent inhibitors of NHE-1 (IC50=3.0±1.6, 3.0±1.4, and 1.6±0.4nmol/l, resp.). Furthermore, they showed a remarkable reduction of infarct size in the rat myocardial infarction model in vivo.

LIGUSTRAZINE AROMATIC ACID ETHER DERIVATIVE, ITS PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION

Ligustrazine aromatic acid ether derivative of general formula I, its preparation method, pharmaceutical composition and application, wherein Ar is selected from aryl substituted aryl and substituted styryl, R is selected from hydrogen and alkyl with no more than 6 carbon atoms.