79074-45-6

Basic information

• Product Name: 2-(BROMOMETHYL)-3,5,6-TRIMETHYLPYRAZINE
• Synonyms: 2-(BROMOMETHYL)-3,5,6-TRIMETHYLPYRAZINE;broMoMethyl-3,5,6-triMethylpyrazine
• CAS NO: 79074-45-6
• Molecular Formula: C₈H₁₁BrN₂
• Molecular Weight: 215.09
• EINECS: 2017-001-1
• Mol File: 79074-45-6.mol
• Article Data: 33

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(BROMOMETHYL)-3,5,6-TRIMETHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)-3,5,6-TRIMETHYLPYRAZINE(79074-45-6)
• EPA Substance Registry System: 2-(BROMOMETHYL)-3,5,6-TRIMETHYLPYRAZINE(79074-45-6)

Safety Data

• Hazardous Substances Data: 79074-45-6(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)-3,5,6-trimethylpyrazine is a chemical compound with the molecular formula C8H12N2Br. It is a pyrazine derivative that is commonly used in the flavor and fragrance industry, contributing to the aroma of roasted or grilled foods. It has a strong, roasted, nutty, and cocoa-like odor and is often used in food products, such as meat, coffee, and chocolate-flavored goods to enhance their taste and aroma. The compound is also used in the manufacturing of various industrial products and may have potential applications in pharmaceuticals and chemical synthesis. It should be handled and stored carefully due to its potentially hazardous nature.

Upstream product

• 1124-11-4 Tetramethylpyrazine 
• 75907-74-3 2-Pyrazinemethanol,3,5,6-trimethyl 
• 79074-43-4 (3,5,6-trimethylpyrazin-2-yl)methyl acetate 
• 22978-83-2 2,3,5,6-tetramethylpyrazine mono N-oxide 
• 76494-51-4 Tetramethylpyrazine hydrochloride 

Downstream Products

• 947243-92-7 ethyl 4-(trifluoromethyl)-2-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate 
• 947243-87-0 ethyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate 
• 947243-83-6 ethyl 3-nitro-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate 
• 947243-94-9 methyl 3-methyl-4-{[(3,5,6-trimethylpyrazin-2-yl)methyl]amino}benzoate 
• 947243-82-5 ethyl 4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate 
• 947243-99-4 ethyl 4-methyl-3-{[(3,5,6-trimethylpyrazin-2-yl)methyl]amino}benzoate 
• 947243-84-7 ethyl 3-bromo-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate 
• 947243-95-0 ethyl 3-bromo-4-{[(3,5,6-trimethylpyrazin-2-yl)methyl]amino}benzoate 
• 947243-97-2 ethyl 3-nitro-4-{[(3,5,6-trimethylpyrazin-2-yl)methyl]amino}benzoate 
• 947243-93-8 ethyl 4-{[(3,5,6-trimethylpyrazin-2-yl)methyl]amino}benzoate 
• 947296-82-4 C₁₆H₁₉N₅O₂ 
• 947296-86-8 C₁₇H₂₁N₅O₃ 
• 947296-83-5 C₁₆H₁₈ClN₅O₂ 
• 947296-85-7 C₁₆H₁₈BrN₅O₂ 

Relevant articles and documents

Intramolecular Diels-Alder reaction of pyrazines with an alkenyl side chain

Intramolecular Diels-Alder reaction of a series of pyrazines bearing a 5-membered-ω-alkene side chain in refluxing trifluoroacetic acid led to the formation of bridged tricyclic compounds. These cycloadducts underwent Retro Diels-Alder reaction in refluxing nitrobenzene to give original pyrazines.

Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivatives

Rosiglitazone has shown promising anti-inflammation effect. To develop preferable anti-inflammatory agents, twenty-two rosiglitazone analogs were synthesized and their anti-inflammatory activity was evaluated. Among these compounds, 6i and 6k displayed excellent inhibitory activities on the production of inflammatory mediators, including nitric oxide (NO), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Furthermore, 6i and 6k showed suppression effects on the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, and this suppression effects could be partially reversed by GW9662, which is a peroxisome proliferator-activated receptor γ (PPARγ) antagonist. Additionally, our docking results exhibited the well combination of 6i and 6k to PPARγ. So the anti-inflammation activity of 6i and 6k was due at least in part, to their interaction with PPARγ.

Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C-ring Unit

A series of novel oxazolidinone compounds with a substituted ligustrazine C-ring unit and different substituted groups at the C-5 side chain were designed and synthesized using linezolid as a lead and based on a scaffold hopping strategy. Their antibacterial and anti-inflammatory activities were evaluated. The results of in vitro antibacterial assays showed that all fourteen target compounds displayed potent activity against Gram-positive pathogens, particularly 8b, 13b, 14a, 14b, 15a, and 15b. Moreover, 14a and 14b exhibited significant inhibitory activities on the production of inflammatory mediators, including nitric oxide, interleukin-6, and tumor necrosis factor-alpha. Thus, these derivatives could serve as valuable candidates to develop anti-infective agents for the treatment of chronic wounds.

Application of pyrazine compound in preparation of drugs

The invention relates to an application of a pyrazine compound in preparation of drugs. The drugs can be used for treating neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal dementia (FTD), vascular dementia, HIV-related dementia, multiple sclerosis, progressive lateral sclerosis, Friedreich's ataxia, neuropathic pain or glaucoma, inflammation, oxidative damage, and mitochondrial-related diseases.

Pyrazine derivative, and preparation method and medical use thereof

The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and t