947263-32-3

Basic information

• Product Name: 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran
• Synonyms: 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran
• CAS NO: 947263-32-3
• Molecular Weight: 248.684
• Mol File: 947263-32-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran(947263-32-3)
• EPA Substance Registry System: 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran(947263-32-3)

Safety Data

• Hazardous Substances Data: 947263-32-3(Hazardous Substances Data)

Upstream product

• 116779-74-9 2-bromo-4-chlorobenzoyl chloride 
• 936-08-3 2-bromo-4-chlorobenzoic acid 
• 98242-53-6 1-(4-chloro-2-hydroxymethylphenyl)-1-(4-fluorophenyl)methanol 
• 947263-33-4 methyl 2-(4-fluorobenzoyl)-4-chlorobenzoate 
• 947263-30-1 2-(4-fluorobenzoyl)-4-chlorobenzoic acid 
• 947263-29-8 2-cyano-4-chloro-4'-fluorobenzophenone 
• 947263-28-7 2-bromo-4-chloro-4'-fluorobenzophenone 

Downstream Products

• 64169-67-1 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile 
• 59729-33-8 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile 

Relevant articles and documents

Novel and improved process for the preparation of citalopram

A novel process for the preparation of citalopram (1) has been described. The key intermediate 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran- 5-carbonitrile (2) of citalopram is prepared using novel intermediates. The process involves simple acylation, hydrolysis and reduction, which can be easily adapted to commercial scale.