947263-33-4

Upstream product

• 67-56-1 methanol 
• 947263-30-1 2-(4-fluorobenzoyl)-4-chlorobenzoic acid 
• 947263-28-7 2-bromo-4-chloro-4'-fluorobenzophenone 
• 947263-29-8 2-cyano-4-chloro-4'-fluorobenzophenone 
• 936-08-3 2-bromo-4-chlorobenzoic acid 
• 116779-74-9 2-bromo-4-chlorobenzoyl chloride 

Downstream Products

• 98242-53-6 1-(4-chloro-2-hydroxymethylphenyl)-1-(4-fluorophenyl)methanol 
• 947263-32-3 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran 
• 64169-67-1 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile 
• 59729-33-8 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile 

Relevant academic research and scientific papers

Novel and improved process for the preparation of citalopram

A novel process for the preparation of citalopram (1) has been described. The key intermediate 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran- 5-carbonitrile (2) of citalopram is prepared using novel intermediates. The process involves simple acylation, hydrolysis and reduction, which can be easily adapted to commercial scale.